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San Diego's antismoking law – cause of fires and second-hand smoke
Huntington's Disease is a chronic progressive autosomal dominant neurodegenerative disorder. The pathological changes manifest clinically in midlife as a progressive impairment of motor function. In spite of extensive research this devastating hereditary disease remains incurable. The natural alkaloid nicotine present in Nicotiana tabacum is by far the most widely studied substance that originates from tobacco smoke and exhibits widespread pharmacological effects. During the last decade, there has been a rapid explosion of publications reporting the neuroprotective activity of nicotine that clearly suggest that nicotinic acetylcholine receptor (nAChR) in the CNS is a new potential therapeutic target for the management of neurodegenerative diseases. O'Neill et al. have suggested that neuronal nAChRs agonists could provide motor improvement and retard the progressive course of various diseases including Alzheimer's disease, Parkinson's Disease and Huntington's Disease. Furthermore, nicotine has been shown to protect various neurons against a variety of neurotoxins via nAChRs. (M. Tariq et al, Brain Research Bulletin 67, 2005) In short, the lady in the apartment smokes to control her Huntington's Disease. And you delicate lilies want her to go live under a bridge! Feh!— January 30, 2011 1:36 a.m.