In the 1960s, the venue at 2228 Bacon Street hosted burlesque clubs such as the Red Garter and the G Lounge. The owner of the property and the building, realtor Sachiko Swall, later opened a live music venue and nightclub at the locale called Dream Street, which operated for nearly two decades. Bands who took the Dream Street stage included Korn (whose appearance there reportedly earned them a record deal), Hole, the Deftones, Sublime, the Melvins, and Candlebox. Dream Street's latter-day owner Billy Savino announced its closure at the beginning of January, 2011.

The owner of Canvas Hair Studio on Garnet Avenue in Pacific Beach, Shelby Wickersheim, assumed the business and its unrestricted liquor license (dancing, live music, liquor pours until 2 a.m.), rechristening the club Mother's. The purchase did not include the land or building title. She and her husband Colin, who owned a silk-screening and embroidery shop in Mira Mesa at the time, spent an estimated $200,000 renovating of the Bacon Street building, including a kitchen addition.

Mother's announced it would be closing in May 2020.