Screamo metalcore band SeeYouSpaceCowboy features former members of René Descartes, alongside members of Letters To Catalonia.

A four-song debut EP was released in 2016, Demo, issued on cassette via Structures/Agony and on CD from React With Protest Records. The following year saw the release of a six-song 7-inch EP, Fashion Statements of the Socially Aware.

The band's equipment van was stolen off SE Hawthorne Boulevard in Portland over the July 8, 2017 weekend. Missing gear and personal belongings include mics, drums, pedals, and amplifiers. Keyboardist-guitarist Taylor Allen cofounded electro-pop duo Mannequin in 2017, alongside bassist-singer David San German.

Their album The Correlation Between Entrance and Exit Wounds was released in 2019. In early 2021, while working on their sophomore album, they released a split-EP on May 14 via Pure Noise with If I Die First, a new metalcore band with emo-trap artist Lil Lotus and From First To Last members Travis Richter and Derek Bloom, alongside fellow emo-trap artists Nedarb and Zubin. Titled A Sure Disaster, the EP features two songs by each band, with SeeYouSpaceCowboy contributing "A Clear Picture from an Unreliable Narrator" and "Modernizing the Myth of Sisyphus." Both bands can be heard on the collaborative track "bloodstainedeyes," also shot as a Cameron Nunez-directed video featuring both bands playing together in a room which is painted half white and half red.

A new single dropped in September 2021 for "Misinterpreting Constellations," in advance of their sophomore album The Romance of Affliction. The record features guests such as singer Keith Buckley (Every Time I Die), singer Aaron Gillespie (Underoath), rapper SHAOLIN G, and members of If I Die First, who released a split-EP with the band earlier this year.

Their 2023 single "Chewing The Scenery," produced by Matt Squire (Underoath, SUM 41, The Used), was released via Pure Noise Records. "This is one of the first songs we wrote when we locked ourselves in a cabin in the Poconos to figure out what we wanted to do with the sound of SYSC moving forward," says frontwoman Connie Sgarbossa. "Somehow, me saying I wanted a waltz part in a song turned into this expansion of the chaotic post hardcore sound we had done on The Romance of Affliction but with sprinkles of new brighter elements we wanted to sprinkle into the new songs that we were making."